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The Effect of Mutating the PDZ domains within s...
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PDZ domains are one of the most common protein-protein interaction domains in human. PDZ domain containing 2 protein (PDZD2) contains 6 PDZ domains and is highly expressed in pancreatic beta cells. It undergoes cleavage in the endoplasmic reticulum to produce a secreted form PDZD2 (sPDZD2) which retains the last two PDZ domains of PDZD2. sPDZD2 is a candidate beta cell regulatory factor. In current study, two mutated forms of sPDZD2 were generated with alterations in the amino acid sequence within the carboxylate-binding loop of one of the two PDZ domains, either at the PDZ5 or at the PDZ6 domain. Current study revealed that both the PDZ5-mutated and PDZ6-mutated sPDZD2 proteins failed to exert the insulinotropic effect that the wildtype sPDZD2 had on INS-1E cells when added exogenously in the culture medium. Both mutant proteins also failed to rescue the silencing action of siRNA on the insulinotropic effect of endogenous PDZD2 in INS-1E cells. These results suggest that intact carboxylate-binding loops of both PDZ5 and PDZ6 domain are crucial for the insulinotropic effect of sPDZD2 exerting on INS-1E cells.

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Stand: 28.01.2020
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Wat, Z: Effect of Mutating the PDZ domains with...
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Erscheinungsdatum: 08/2011, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: The Effect of Mutating the PDZ domains within secreted PDZD2, Titelzusatz: on its insulinotropic action in INS-IE cells, Autor: Wat, Zee man, Winnie, Verlag: LAP Lambert Acad. Publ., Sprache: Englisch, Rubrik: Genetik // Gentechnologie, Seiten: 96, Informationen: Paperback, Gewicht: 159 gr, Verkäufer: averdo

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Stand: 28.01.2020
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Feminist Critical Discourse Analysis
58,33 € *
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The first collection to bring together well-known scholars writing from feminist perspectives within Critical Discourse Analysis. The theoretical structure of CDA is illustrated with empirical research from a range of locations (from Europe to Asia, the USA to Australasia) and domains (from parliament to the classroom, the media to the workplace).

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Information Structure Within Interfaces
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The realization of information structural units has been intriguing as information packaging has reflections in the semantic, pragmatic, syntactic and prosodic domains. This book extends the investigation by bringing data from all these domains and presenting an analysis for the model of grammar.Based on three-way classification for information packaging, semantic investigation presents insights on compositionality and positional restrictions for topic, focus and discourse anaphoric phrases. The prosodic experimental studies reveal how focus shapes prosody and how diverse languages encode such information packaging. Drawing on the findings of experimental studies reflecting the interaction of information structure with quantifier scope, negation and aspectual markers,clause internal functional projections and scope domains are proposed in the syntactic analysis. The analysis offers new perspectives for movement operations, functional categories, phases which are central themes for the Minimalist Program.Building on the investigation of information structure within semantic, prosodic, syntactic perspectives, the book will appeal to researchers working on either of these domains or their interfaces.

Anbieter: Dodax
Stand: 28.01.2020
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A Wittgensteinian Perspective on the Use of Con...
89,48 € *
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This edited volume includes contributions from internationally renowned experts in the philosophy of Ludwig Wittgenstein. It applies his later philosophy to concrete issues pertaining to the integrity of scientific claims in a broad spectrum of research domains within contemporary psychology.

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Feminist Critical Discourse Analysis
57,63 € *
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The first collection to bring together well-known scholars writing from feminist perspectives within Critical Discourse Analysis. The theoretical structure of CDA is illustrated with empirical research from a range of locations (from Europe to Asia, the USA to Australasia) and domains (from parliament to the classroom, the media to the workplace).

Anbieter: Dodax
Stand: 28.01.2020
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A Wittgensteinian Perspective on the Use of Con...
90,13 € *
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This edited volume includes contributions from internationally renowned experts in the philosophy of Ludwig Wittgenstein. It applies his later philosophy to concrete issues pertaining to the integrity of scientific claims in a broad spectrum of research domains within contemporary psychology.

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Stand: 28.01.2020
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Reconceptualizing Crime as an Independent Variable
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As a discipline, criminology has long focused its attention on explaining crime and has thus placed crime almost exclusively as an outcome. As a result, little attention has been paid to the effect that criminal involvement has on other social domains, such as education, work, and relationships. To do so, criminal behavior must be understood as one of several social domains that interact within the broader context of social development. Grounded in this developmental perspective, this research used the National Longitudinal Survey of Youth, 1997 to examine the consequences of adolescent criminal involvement on social development in early adulthood. In all, the results suggest that adolescent criminal involvement has a detrimental impact on a variety of social outcomes in early adulthood. The data also suggest that social outcomes are interrelated and that criminal involvement is better viewed as one of a variety of social domains which are connected within the context of general social development.

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What Works In Online Classrooms
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Research into the field of teaching and learning in higher education has discovered key elements that impact student satisfaction and academic achievement. One key to enhancing teaching effectiveness is positive social-emotional environments in classrooms. The advent of online classrooms brings with it the challenge of whether or not what is known about face-to-face classrooms applies in virtual environments. Using a validated survey instrument developed for face-to-face classroom settings, this study surveyed students to determine differences between graduate and undergraduate students' perceptions. The study examined the variables within seven psycho-social domains. Of the seven domains within the survey instrument a stronger relationship was suggested among these domains: Innovation, Task Orientation, and Cohesiveness. The results of the study suggest positive student perception of virtual classroom environment is not dependent on instructors having completed formal mentoring to teach online. Further, students in graduate online courses (defined as adults) perceived their online environments more positively than students (emerging adults) in undergraduate online courses.

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Stand: 28.01.2020
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