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Using Mass Spectrometry for Biochemical Studies...
98,77 € *
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This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis.In addition, the ability to alter the substrate tolerance of KS domains by simple point mutations in the active site has been demonstrated. A series of acyl-ACPs have been synthesised using a novel methodology and employed to probe the substrate specificity of both KS domains and the previously uncharcterised acyl hydrolase domain, PedC.KS-catalysed chain elongation reactions have also been conducted and monitored by ESI-MS/MS. All KS domains studied exhibited higher substrate specificity at the elongation step than in the preceeding acylation step. Furthermore, a mechanism of reversible acylation is proposed using the PsyA ACP1-KS1 di-domain. The findings in this thesis provide important insights into mechanisms of KS specificity and show that mutagenesis can be used to expand the repertoire of acceptable substrates for future PKS engineering.

Anbieter: Dodax AT
Stand: 28.01.2020
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Integrating Face and Voice in Person Perception
200,97 € *
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This book follows a successful symposium organized in June 2009 at the Human Brain Mapping conference. The topic is at the crossroads of two domains of increasing importance and appeal in the neuroimaging/neuroscience community: multi-modal integration, and social neuroscience.Most of our social interactions involve combining information from both the face and voice of other persons: speech information, but also crucial nonverbal information on the person's identity and affective state. The cerebral bases of the multimodal integration of speech have been intensively investigated, by contrast only few studies have focused on nonverbal aspects of face-voice integration.This work highlights recent advances in investigations of the behavioral and cerebral bases of face-voice multimodal integration in the context of person perception, focusing on the integration of affective and identity information.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.

Anbieter: Dodax AT
Stand: 28.01.2020
Zum Angebot
Integrating Face and Voice in Person Perception
200,97 € *
ggf. zzgl. Versand

This book follows a successful symposium organized in June 2009 at the Human Brain Mapping conference. The topic is at the crossroads of two domains of increasing importance and appeal in the neuroimaging/neuroscience community: multi-modal integration, and social neuroscience.Most of our social interactions involve combining information from both the face and voice of other persons: speech information, but also crucial nonverbal information on the person's identity and affective state. The cerebral bases of the multimodal integration of speech have been intensively investigated, by contrast only few studies have focused on nonverbal aspects of face-voice integration.This work highlights recent advances in investigations of the behavioral and cerebral bases of face-voice multimodal integration in the context of person perception, focusing on the integration of affective and identity information.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.

Anbieter: Dodax
Stand: 28.01.2020
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Information Structure Within Interfaces
99,95 € *
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The realization of information structural units has been intriguing as information packaging has reflections in the semantic, pragmatic, syntactic and prosodic domains. This book extends the investigation by bringing data from all these domains and presenting an analysis for the model of grammar.Based on three-way classification for information packaging, semantic investigation presents insights on compositionality and positional restrictions for topic, focus and discourse anaphoric phrases. The prosodic experimental studies reveal how focus shapes prosody and how diverse languages encode such information packaging. Drawing on the findings of experimental studies reflecting the interaction of information structure with quantifier scope, negation and aspectual markers,clause internal functional projections and scope domains are proposed in the syntactic analysis. The analysis offers new perspectives for movement operations, functional categories, phases which are central themes for the Minimalist Program.Building on the investigation of information structure within semantic, prosodic, syntactic perspectives, the book will appeal to researchers working on either of these domains or their interfaces.

Anbieter: Dodax
Stand: 28.01.2020
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Evolutionary conserved features of FG repeats t...
29,03 € *
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Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain ‘cohesive’ FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.

Anbieter: Dodax AT
Stand: 28.01.2020
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Evolutionary conserved features of FG repeats t...
29,03 € *
ggf. zzgl. Versand

Non-globular FG domains constitute the permeability barrier of nuclear pore complexes (NPCs), which control all macromolecular exchange between nucleus and cytoplasm. Whilst objects smaller than 30kDa can passively diffuse across this barrier, larger molecules need to be chaperoned by nuclear transport receptors (NTRs). However, the modus operandi and, inextricably linked, the exact physical nature of the NPC permeability barrier are still controversially discussed. Whereas so far, most studies exclusively focused on yeast or vertebrate FG domains, the ability of FG domains from different species to form selective barriers was explored here. Interestingly, all studied species contain ‘cohesive’ FG domains that interact with each other to form a characteristic (hydrogel) phase mimicking the permeability properties of NPCs.

Anbieter: Dodax
Stand: 28.01.2020
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Impulsive Systems on Hybrid Time Domains
82,85 € *
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This monograph discusses the issues of stability and the control of impulsive systems on hybrid time domains, with systems presented on discrete-time domains, continuous-time domains, and hybrid-time domains (time scales). Research on impulsive systems has recently attracted increased interest around the globe, and significant progress has been made in the theory and application of these systems. This book introduces recent developments in impulsive systems and fundamentals of various types of differential and difference equations. It also covers studies in stability related to time delays and other various control applications on the different impulsive systems. In addition to the analyses presented on dynamical systems that are with or without delays or impulses, this book concludes with possible future directions pertaining to this research.

Anbieter: Dodax AT
Stand: 28.01.2020
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Impulsive Systems on Hybrid Time Domains
80,76 € *
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This monograph discusses the issues of stability and the control of impulsive systems on hybrid time domains, with systems presented on discrete-time domains, continuous-time domains, and hybrid-time domains (time scales). Research on impulsive systems has recently attracted increased interest around the globe, and significant progress has been made in the theory and application of these systems. This book introduces recent developments in impulsive systems and fundamentals of various types of differential and difference equations. It also covers studies in stability related to time delays and other various control applications on the different impulsive systems. In addition to the analyses presented on dynamical systems that are with or without delays or impulses, this book concludes with possible future directions pertaining to this research.

Anbieter: Dodax
Stand: 28.01.2020
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A Document (Re)turn
78,95 € *
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When people are checking in to flights, making reports to their company manager, composing music, delivering papers for exams in schools, or examining patients in hospitals, they all deal with documents and processes of documentation. In earlier times, documentation took place primarily in libraries and archives. While the latter are still important document institutions, documents today play a far more essential role in social life in many different domains and cultures. In this book, which celebrates the ten year anniversary of documentation studies in Tromsø, experts from many different disciplines, professional domains as well as cultures around the world present their way of dealing with documents, demonstrating many potential directions for the emerging broad field of documentation studies.

Anbieter: Dodax
Stand: 28.01.2020
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