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The Effect of Mutating the PDZ domains within s...
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The Effect of Mutating the PDZ domains within secreted PDZD2 ab 49 EURO on its insulinotropic action in INS-IE cells

Anbieter: ebook.de
Stand: 04.08.2020
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The Effect of Mutating the PDZ domains within s...
49,00 € *
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PDZ domains are one of the most common protein-protein interaction domains in human. PDZ domain containing 2 protein (PDZD2) contains 6 PDZ domains and is highly expressed in pancreatic beta cells. It undergoes cleavage in the endoplasmic reticulum to produce a secreted form PDZD2 (sPDZD2) which retains the last two PDZ domains of PDZD2. sPDZD2 is a candidate beta cell regulatory factor. In current study, two mutated forms of sPDZD2 were generated with alterations in the amino acid sequence within the carboxylate-binding loop of one of the two PDZ domains, either at the PDZ5 or at the PDZ6 domain. Current study revealed that both the PDZ5-mutated and PDZ6-mutated sPDZD2 proteins failed to exert the insulinotropic effect that the wildtype sPDZD2 had on INS-1E cells when added exogenously in the culture medium. Both mutant proteins also failed to rescue the silencing action of siRNA on the insulinotropic effect of endogenous PDZD2 in INS-1E cells. These results suggest that intact carboxylate-binding loops of both PDZ5 and PDZ6 domain are crucial for the insulinotropic effect of sPDZD2 exerting on INS-1E cells.

Anbieter: Dodax
Stand: 04.08.2020
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Sema Domain
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in P08581 the hepatocyte growth factor receptor and P51805 and in viral proteins. CD100 (also called SEMA4D) is associated with PTPase and serine kinase activity. CD100 increases PMA, CD3 and CD2 induced T cell proliferation, increases CD45 induced T cell adhesion, induces B cell homotypic adhesion and down-regulates B cell expression of CD23.

Anbieter: Dodax
Stand: 04.08.2020
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Extracellular Composite Matrices in Arthropods
316,00 CHF *
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Emphasis is placed on the elaborate cuticular matrices in insects and crustaceans, spider and insect silks, sialomes of phytophagous and blood-feeding arthropods as well as on secretions of male and female accessory glands. Focus is placed largely on insects, due to the extensive body of published research that in part is the result of available whole genome sequences of several model species (in particular Drosophila melanogaster) and accessible ESTs for other species. Such advances have facilitated fundamental insights into genomic, proteomic and molecular biology-based physiology. This new volume contains comprehensive contributions on extracellular composite matrices in arthropods. The building blocks of such matrices are formed in and secreted by single layered epithelial cells into exterior domains where their final assembly takes place.Additionally, the unique mechanical properties of natural biocomposites like chitin/chitosan, the crustacean mineralized exoskeleton, the pliant protein resilin or insect and spider silks, have inspired basic and applied research that yield sophistical biomimetics and structural biocomposite hybrids important for future industrial and biomedical use. In summary, this book provides an invaluable vast source of basic and applied information for a plethora of scientists as well as textbook for graduate and advanced undergraduate students.

Anbieter: Orell Fuessli CH
Stand: 04.08.2020
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Extracellular Composite Matrices in Arthropods
243,99 € *
ggf. zzgl. Versand

Emphasis is placed on the elaborate cuticular matrices in insects and crustaceans, spider and insect silks, sialomes of phytophagous and blood-feeding arthropods as well as on secretions of male and female accessory glands. Focus is placed largely on insects, due to the extensive body of published research that in part is the result of available whole genome sequences of several model species (in particular Drosophila melanogaster) and accessible ESTs for other species. Such advances have facilitated fundamental insights into genomic, proteomic and molecular biology-based physiology. This new volume contains comprehensive contributions on extracellular composite matrices in arthropods. The building blocks of such matrices are formed in and secreted by single layered epithelial cells into exterior domains where their final assembly takes place.Additionally, the unique mechanical properties of natural biocomposites like chitin/chitosan, the crustacean mineralized exoskeleton, the pliant protein resilin or insect and spider silks, have inspired basic and applied research that yield sophistical biomimetics and structural biocomposite hybrids important for future industrial and biomedical use. In summary, this book provides an invaluable vast source of basic and applied information for a plethora of scientists as well as textbook for graduate and advanced undergraduate students.

Anbieter: Thalia AT
Stand: 04.08.2020
Zum Angebot
The Effect of Mutating the PDZ domains within s...
43,99 € *
ggf. zzgl. Versand

PDZ domains are one of the most common protein-protein interaction domains in human. PDZ domain containing 2 protein (PDZD2) contains 6 PDZ domains and is highly expressed in pancreatic beta cells. It undergoes cleavage in the endoplasmic reticulum to produce a secreted form PDZD2 (sPDZD2) which retains the last two PDZ domains of PDZD2. sPDZD2 is a candidate beta cell regulatory factor. In current study, two mutated forms of sPDZD2 were generated with alterations in the amino acid sequence within the carboxylate-binding loop of one of the two PDZ domains, either at the PDZ5 or at the PDZ6 domain. Current study revealed that both the PDZ5-mutated and PDZ6-mutated sPDZD2 proteins failed to exert the insulinotropic effect that the wildtype sPDZD2 had on INS-1E cells when added exogenously in the culture medium. Both mutant proteins also failed to rescue the silencing action of siRNA on the insulinotropic effect of endogenous PDZD2 in INS-1E cells. These results suggest that intact carboxylate-binding loops of both PDZ5 and PDZ6 domain are crucial for the insulinotropic effect of sPDZD2 exerting on INS-1E cells.

Anbieter: Thalia AT
Stand: 04.08.2020
Zum Angebot