Angebote zu "Membrane" (93 Treffer)

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Membrane Dynamics and Domains
241,79 € *
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Erscheinungsdatum: 07.12.2010, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Membrane Dynamics and Domains, Titelzusatz: Subcellular Biochemistry, Auflage: Softcover reprint of the original 1st ed. 2004, Redaktion: Quinn, Peter J., Verlag: Springer US, Sprache: Englisch, Schlagworte: Biochemie, Rubrik: Biochemie // Biophysik, Seiten: 520, Informationen: Paperback, Gewicht: 745 gr, Verkäufer: averdo

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Stand: 24.01.2020
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Kucherak, Oleksandr: Fluorescent Membrane Probe...
59,00 € *
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Erscheinungsdatum: 08/2012, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Fluorescent Membrane Probes for Apoptosis and Raft Domains, Titelzusatz: Design, Synthesis and Application, Autor: Kucherak, Oleksandr, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Chemie // Populäre Darstellungen, Seiten: 156, Informationen: Paperback, Gewicht: 249 gr, Verkäufer: averdo

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Production of Membrane Proteins
112,93 € *
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Designed as a research-level guide to current strategies and methods of membrane protein production on the small to intermediate scale, this practice-oriented book provides detailed, step-by-step laboratory protocols as well as an explanation of the principles behind each method, together with a discussion of its relative advantages and disadvantages. Following an introductory section on current challenges in membrane protein production, the book goes on to look at expression systems, emerging methods and approaches, and protein specific considerations.Case studies illustrate how to select or sample the optimal production system for any desired membrane protein, saving both time and money on the laboratory as well as the technical production scale.Unique in its coverage of "difficult" proteins with large membrane-embedded domains, proteins from extremophiles, peripheral membrane proteins, and protein fragments.

Anbieter: Dodax
Stand: 24.01.2020
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Production of Membrane Proteins
114,16 € *
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Designed as a research-level guide to current strategies and methods of membrane protein production on the small to intermediate scale, this practice-oriented book provides detailed, step-by-step laboratory protocols as well as an explanation of the principles behind each method, together with a discussion of its relative advantages and disadvantages. Following an introductory section on current challenges in membrane protein production, the book goes on to look at expression systems, emerging methods and approaches, and protein specific considerations.Case studies illustrate how to select or sample the optimal production system for any desired membrane protein, saving both time and money on the laboratory as well as the technical production scale.Unique in its coverage of "difficult" proteins with large membrane-embedded domains, proteins from extremophiles, peripheral membrane proteins, and protein fragments.

Anbieter: Dodax AT
Stand: 24.01.2020
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UPK1A
40,10 € *
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High Quality Content by WIKIPEDIA articles! Uroplakin-1a is a protein that in humans is encoded by the UPK1A gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.

Anbieter: Dodax AT
Stand: 24.01.2020
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Theoretical and Simulation Study of Lipid Membr...
60,70 € *
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Proper functioning of biological membranes is inlarge part due to cholesterol's ability to regulatefluidity of a lipid bilayer. The evidence suggeststhat cholesterol participates in the formation ofcholesterol- and sphingolipid-enriched domains knownas rafts in the plasma and other membranes ofanimal cells. Rafts have been identified as animportant membrane structural units in signaltransduction, protein transport and sorting ofmembrane components. The goal of this research is tomodel raft-like membrane domains with tools ofcomputational biophysics. In the first part of thework, mixtures of sphingomyelin lipid and cholesterolare investigated using molecular dynamics andMonte-Carlo simulations. In the second part of thebook, a novel dynamic mean-field model is developedto investigate phase properties of lipid-cholesterolmembranes. This new technique allows studying largebilayer patches on microsecond timescales, and haspowerful predictive capability. The material in thisbook is most suitable for computational biophysicistsand biologists, as well as for scientists working instatistical and condensed matter physics fields.

Anbieter: Dodax AT
Stand: 24.01.2020
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Theoretical and Simulation Study of Lipid Membr...
59,00 € *
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Proper functioning of biological membranes is inlarge part due to cholesterol's ability to regulatefluidity of a lipid bilayer. The evidence suggeststhat cholesterol participates in the formation ofcholesterol- and sphingolipid-enriched domains knownas rafts in the plasma and other membranes ofanimal cells. Rafts have been identified as animportant membrane structural units in signaltransduction, protein transport and sorting ofmembrane components. The goal of this research is tomodel raft-like membrane domains with tools ofcomputational biophysics. In the first part of thework, mixtures of sphingomyelin lipid and cholesterolare investigated using molecular dynamics andMonte-Carlo simulations. In the second part of thebook, a novel dynamic mean-field model is developedto investigate phase properties of lipid-cholesterolmembranes. This new technique allows studying largebilayer patches on microsecond timescales, and haspowerful predictive capability. The material in thisbook is most suitable for computational biophysicistsand biologists, as well as for scientists working instatistical and condensed matter physics fields.

Anbieter: Dodax
Stand: 24.01.2020
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Diversity in Molecular Recognition of Phospholi...
79,00 € *
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Phospholipid-binding domains are key components ofsignaling pathways that normally drive membranerecruitment of their host protein in vivo. The mostnumerous Pleckstrin Homology (PH) domains arecommonly associated with high affinity,phosphoinositide (PPIns)-specific binding in vitroand membrane-specific targeting in vivo. In fact, themajority of PH domains bind PPIns promiscuously andwith low affinity in vitro and are diffuselylocalized in vivo. A novel class of PH domains -belonging to the OSBP/FAPP family - is identifiedhere with distinct phospholipid-binding properties,having both promiscuous and high affinity for PPInsin vitro. Additionally, thecrystal structure of amember of this class - Osh1p PH - has been determinedat high resolution. The PPIns-binding properties ofanother unusual PH domain, belonging to SH3BP2, isalso discussed, which has implications in the spatialand temporal regulation of 3-phosphoinositides.Finally, an alkylphospholipid drug is identified thatinteracts directly with the PH domain ofAkt1/PKBalpha in vitro, which has implications in theuse of PH domains as possible targets for therapeuticdrug intervention.

Anbieter: Dodax
Stand: 24.01.2020
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Diversity in Molecular Recognition of Phospholi...
81,30 € *
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Phospholipid-binding domains are key components ofsignaling pathways that normally drive membranerecruitment of their host protein in vivo. The mostnumerous Pleckstrin Homology (PH) domains arecommonly associated with high affinity,phosphoinositide (PPIns)-specific binding in vitroand membrane-specific targeting in vivo. In fact, themajority of PH domains bind PPIns promiscuously andwith low affinity in vitro and are diffuselylocalized in vivo. A novel class of PH domains -belonging to the OSBP/FAPP family - is identifiedhere with distinct phospholipid-binding properties,having both promiscuous and high affinity for PPInsin vitro. Additionally, thecrystal structure of amember of this class - Osh1p PH - has been determinedat high resolution. The PPIns-binding properties ofanother unusual PH domain, belonging to SH3BP2, isalso discussed, which has implications in the spatialand temporal regulation of 3-phosphoinositides.Finally, an alkylphospholipid drug is identified thatinteracts directly with the PH domain ofAkt1/PKBalpha in vitro, which has implications in theuse of PH domains as possible targets for therapeuticdrug intervention.

Anbieter: Dodax AT
Stand: 24.01.2020
Zum Angebot