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The Effect of Mutating the PDZ domains within s...
49,00 € *
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PDZ domains are one of the most common protein-protein interaction domains in human. PDZ domain containing 2 protein (PDZD2) contains 6 PDZ domains and is highly expressed in pancreatic beta cells. It undergoes cleavage in the endoplasmic reticulum to produce a secreted form PDZD2 (sPDZD2) which retains the last two PDZ domains of PDZD2. sPDZD2 is a candidate beta cell regulatory factor. In current study, two mutated forms of sPDZD2 were generated with alterations in the amino acid sequence within the carboxylate-binding loop of one of the two PDZ domains, either at the PDZ5 or at the PDZ6 domain. Current study revealed that both the PDZ5-mutated and PDZ6-mutated sPDZD2 proteins failed to exert the insulinotropic effect that the wildtype sPDZD2 had on INS-1E cells when added exogenously in the culture medium. Both mutant proteins also failed to rescue the silencing action of siRNA on the insulinotropic effect of endogenous PDZD2 in INS-1E cells. These results suggest that intact carboxylate-binding loops of both PDZ5 and PDZ6 domain are crucial for the insulinotropic effect of sPDZD2 exerting on INS-1E cells.

Anbieter: Dodax
Stand: 28.01.2020
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Wat, Z: Effect of Mutating the PDZ domains with...
49,00 € *
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Erscheinungsdatum: 08/2011, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: The Effect of Mutating the PDZ domains within secreted PDZD2, Titelzusatz: on its insulinotropic action in INS-IE cells, Autor: Wat, Zee man, Winnie, Verlag: LAP Lambert Acad. Publ., Sprache: Englisch, Rubrik: Genetik // Gentechnologie, Seiten: 96, Informationen: Paperback, Gewicht: 159 gr, Verkäufer: averdo

Anbieter: averdo
Stand: 28.01.2020
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Diamagnetic domains in non-magnetic metals
59,00 € *
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Diamagnetic domains called "Condon domains" are investigaited.The origin of these domains is Landau levels arising in a magnetic field and low temperatures in the perfect crystals leading to the de Haas-van Alphen (dHvA) effect and domains arising in non-magnetic metals. The differet methods were used. For the first time, by muons the domains were found in all measured metals, by micro-Hall probes domain sructutr was detected on silver, magnetostriction was measured in beryllium, hysteresis was observed in dHvA effect and experimental phase diagram of the Condon domain state are determined for silver and beryllium.

Anbieter: Dodax
Stand: 28.01.2020
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Diamagnetic domains in non-magnetic metals
60,70 € *
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Diamagnetic domains called "Condon domains" are investigaited.The origin of these domains is Landau levels arising in a magnetic field and low temperatures in the perfect crystals leading to the de Haas-van Alphen (dHvA) effect and domains arising in non-magnetic metals. The differet methods were used. For the first time, by muons the domains were found in all measured metals, by micro-Hall probes domain sructutr was detected on silver, magnetostriction was measured in beryllium, hysteresis was observed in dHvA effect and experimental phase diagram of the Condon domain state are determined for silver and beryllium.

Anbieter: Dodax AT
Stand: 28.01.2020
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Substitutional Diffusion
35,90 € *
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Mohamed Atef has used the set theory to build mathematical model for magnetc transitions. This book studies the effect of diffusion on the residual magnetic domains using advanced mathematics. The work is based on the author's research accepted in the Journal of "Theoretical mathematics and Applications".

Anbieter: Dodax
Stand: 28.01.2020
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Substitutional Diffusion
37,00 € *
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Mohamed Atef has used the set theory to build mathematical model for magnetc transitions. This book studies the effect of diffusion on the residual magnetic domains using advanced mathematics. The work is based on the author's research accepted in the Journal of "Theoretical mathematics and Applications".

Anbieter: Dodax AT
Stand: 28.01.2020
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Handbook of Ripple Effects in the Supply Chain
112,98 € *
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This book offers an introduction to the ripple effect in the supply chain for a broad audience comprising recent developments. The chapters of this handbook are written by leading experts in supply chain risk management and resilience. For the first time, the chapters present in their synergy a multiple-faceted view of the ripple effect in supply chains, while considering organization, optimization, and informatics perspectives. Ripple effect describes the impact of a disruption propagation on supply chain performance, structural designs and operational parameters. The ripple effect manifests when the impact of a disruption cannot be localized and cascades along the supply chain. The resulting structural dynamics can lead to capacity and demand fulfilment downscaling and negatively influence the firm's financial and operational performance. The book delineates major features of the ripple effect and methodologies to mitigate the adverse impact of supply chain disruption propagation and to recover in case of severe disruptions. The book provides fresh insights for supply chain management and engineering regarding the following questions: - In what circumstance does one failure cause other failures? - Which structures of the supply chain are especially susceptible to the ripple effect? - What are the typical ripple effect scenarios and what are the most efficient ways to respond them? Distinctive Features: - It considers ripple effect in the supply chain from an multi-disciplinary perspective - It offers an introduction to ripple effect mitigation and recovery policies in the framework of disruption risk management in supply chains for a broad audience - It integrates management and engineering perspectives on disruption risk management in the supply chain - It presents innovative optimization and simulation models for real-life management problems - It considers examples from both industrial and service supply chains - It reveals decision-making recommendations for tackling disruption risks in the supply chain in proactive and reactive domains.

Anbieter: Dodax AT
Stand: 28.01.2020
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Theoretical Principles of Sociology, Volume 2. ...
160,49 € *
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Micro-level dynamics revolve around face-to-face interactions among individuals. What occurs within encounters is constrained by their embedding with corporate and categoric units and, by extension, institutional domains, stratification systems, community networks, societies, and inter-societal systems. In this Handbook, the author explores the effect of microdynamics on these larger social systems.

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Stand: 28.01.2020
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Theoretical Principles of Sociology, Volume 2
160,49 € *
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Micro-level dynamics revolve around face-to-face interactions among individuals. What occurs within encounters is constrained by their embedding with corporate and categoric units and, by extension, institutional domains, stratification systems, community networks, societies, and inter-societal systems. In this Handbook, the author explores the effect of microdynamics on these larger social systems.

Anbieter: Dodax
Stand: 28.01.2020
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