In search of molecular domains ab 67.9 € als Taschenbuch: Exploring the effect of specific subunit domains on the differential localization of GABA (A) receptor subtypes. Aus dem Bereich: Bücher, Wissenschaft, Biologie,
There's always been something universalizing about the Internet. The World Wide Web has seemed both inherently singular and global, a sort of ethereal United Nations. But today, as Scott Malcomson contends in this concise, brilliant investigation, the Internet is cracking apart into discrete groups no longer willing, or able, to connect. The implications of this shift are momentous. Malcomson traces the way the Internet has been shaped by government needs since the 19th century - above all, the demands of the US military and intelligence services. From World War I cryptography and spying to weapons targeting against Hitler and then Stalin, the monolithic aspect of the digital network was largely determined by its genesis in a single, state-sponsored institution. In the 1960s, internationalism and openness were introduced by the tech pioneers of California's counter-culture, the seed bed for what became Google, Microsoft, Facebook, and Apple. But in the last 15 years, security concerns of states and the privatizing impetus of e-commerce have come to the fore and momentum has shifted in a new direction, towards private, walled domains, each vying with the other in an increasingly fragmented system, in effect a "Splinternet". Because the Internet today surrounds us so comprehensively, it's easy to regard the way it functions as a simple given, part of the natural order of things. Only by stepping back and scrutinizing the evolution of the system can we see the Internet for what it is - a contested, protean terrain, constantly evolving as different forces intervene to drive it forward. In that vital exercise, Malcomson's elegant, erudite account will prove invaluable. 1. Language: English. Narrator: Jonathan Yen. Audio sample: http://samples.audible.de/bk/adbl/028154/bk_adbl_028154_sample.mp3. Digital audiobook in aax.
The industrial and organizational psychology is defined as “the branch of psychology that makes use of psychological theories and principles to organizations.” It is abbreviated as I/O psychology. The main area of concern of an I-O psychologist is to resolve issues such as increasing work-place productivity, ensuring proper physical and mental well-being of the people working within the industry, etc.To find appropriate solutions to the issues, an industrial and organizational psychologist is required to perform a variety of tasks such as conducting leadership training, carrying out an evaluation of companies, studying the attitudes and behavior of the workers employed in the companies.The industrial and organizational psychology is comprised of the two sides namely, the industrial and the organizational side of psychology, both of which focus on entirely different perspectives however they are not very different from each other in terms of their applications, their goals and their topics of interest.The emergence of World War I and World War II helped in making significant changes in the field of industrial and organizational psychology. After the breakout of World War II, the APA began to look strictly into the proceedings of the I/O psychology and formulated the Division 14, industrial and business psychology.The I/O psychologist are trained to perform several qualitative and quantitative studies and tests on the individual working within an industry or organization in order to provide appropriate solutions to their problems which are characterized by the professional practice domains of an I/O psychologist.To help with keeping the psychological matters of a company under control of the industrial and organizational branch of psychology comes into effect. 1. Language: English. Narrator: Andrea Giordani. Audio sample: http://samples.audible.de/bk/acx0/149867/bk_acx0_149867_sample.mp3. Digital audiobook in aax.
Learn strategy with 300 quotes by Napoleon Bonaparte, Sun Tzu and Machiavelli. "The Prince" is the most famous of Machiavelli's works; it gives very clear, precise and realistic instructions on how to gain and maintain power, fortune, and glory, sometimes at the expense of others. Written in 1513, it is one of the most feared and hated political treatises, taken to be the first work in which the effect the leader desires to achieve is taken as more important than any abstract ideal or ethical value that might prevent him from taking immoral action. We have selected for you 100 of the best quotes from "The Prince", trusting that you will be able to use their efficiency and cleverness to direct your own affairs in a powerful way without falling into a moral trap. Sun Tzu was a revered Chinese general, strategist, and philosopher. He is credited with one of the most influential military treatises ever written, "The Art of War". Countless leaders have drawn inspiration from this work, from Mao Zedong to General Douglas MacArthur. It is so powerful and straightforward that it is still influencing many domains other than military thinking, like business tactics, legal strategy, entrepreneurship, and beyond. We have selected from you 100 of Sun Tzu's most powerful quotes, for you to gain a new understanding in interpersonal dynamics, strategy, and everyday life. Napoleon Bonaparte was one of the greatest military figures ever. He rose to prominence during the French Revolution, after which he kept on soaring higher and higher until he was crowned Emperor of the French. He then moved on to gain control of the whole of continental Europe before the ultimate defeat of 1815. Today, his campaigns are studied in every military school, his liberal politics have had a strong legacy worldwide, and he remains one of the most celebrated and controversial political figures in Western history. Napoleon's style is clear, concise, sometimes p 1. Language: English. Narrator: Katie Haigh. Audio sample: http://samples.audible.de/bk/cids/000764/bk_cids_000764_sample.mp3. Digital audiobook in aax.
The Effect of Mutating the PDZ domains within secreted PDZD2 ab 49 EURO on its insulinotropic action in INS-IE cells
PDZ domains are one of the most common protein-protein interaction domains in human. PDZ domain containing 2 protein (PDZD2) contains 6 PDZ domains and is highly expressed in pancreatic beta cells. It undergoes cleavage in the endoplasmic reticulum to produce a secreted form PDZD2 (sPDZD2) which retains the last two PDZ domains of PDZD2. sPDZD2 is a candidate beta cell regulatory factor. In current study, two mutated forms of sPDZD2 were generated with alterations in the amino acid sequence within the carboxylate-binding loop of one of the two PDZ domains, either at the PDZ5 or at the PDZ6 domain. Current study revealed that both the PDZ5-mutated and PDZ6-mutated sPDZD2 proteins failed to exert the insulinotropic effect that the wildtype sPDZD2 had on INS-1E cells when added exogenously in the culture medium. Both mutant proteins also failed to rescue the silencing action of siRNA on the insulinotropic effect of endogenous PDZD2 in INS-1E cells. These results suggest that intact carboxylate-binding loops of both PDZ5 and PDZ6 domain are crucial for the insulinotropic effect of sPDZD2 exerting on INS-1E cells.
The transition from primary to secondary school appears to have a disturbing effect on some adolescents. The psychological reasons, why some students give up and refuse to learn is the focus of this book which attempts to discover if learned helplessness exists among Barbadian adolescents, and to examine the relationship between a number of psychosocial variables. The instruments employed in this study identified adolescents who exhibited learned helplessness deficit behaviours in the classroom and have a pessimistic explanatory style. They also found deficits in the behavioural, cognitive and emotional domains of learned helplessness. The implications of these results focus on interventions which are consistent with the challenges that adolescents with learned helplessness or school achievement problems experience. This book provides information to educators who work with adolescents about factors that contribute to student achievement and failure in Barbados' somewhat elitist secondary education system.
Many researchers have investigated the acceptance of information technology in a wide range of organizational contexts and subject domains. However, the prominent model frameworks seem to view the phenomenon through specific and rather restricted lenses. The objectives of this research study are thus to examine and develop an integrated model that explains information technology acceptance from several perspectives within a particular organizational context, and to determine whether the model explains adoption behavior over time. An integrated model that is composed of the social perspective (subjective norm), the technology perspective (perceived usefulness and perceived ease of use), and the-self perspective (computer self-efficacy) better explains information technology acceptance than the models commonly used in past information technology research. A longitudinal field study shows that the key determinants of intention to use a system diminish in effect over a prolonged period. Some implications of these findings for academics and practitioners in designing and implementing information technology strategies are presented.